Two engines has never been an option. The same issue arose with the KC-135 upgrade. It would cost too much to re-engineer the wings, pylons, flight controls, and systems. Hence the KC-135 retained 4 motors on 4 pylons. The B-52 upgrade studies of the past did the same; kept 4 motors on the 4 available pylons.
With that; in the interest of saving the USAF money and capitalizing on existing contracts and infrastructure; I'd opt for the F117 of the C-17 @ 40.4K thrust. We can call it the F117-PW-200. There are over 1000 F117 engines currently in use with the USAF. Logistics are in place and much experience has been gained with this military version of the PW2000 commercial engine. Many common parts would be available worldwide.
The F108 of the KC-135 could be an option as well; many 'used motors' would be available as the new KC-46 comes online and the KC-135s are sent to the bone yard. Downfall to this is only 27K thrust which equal to combined twin J57-P-43WB of the older B-52G, but lower than the combined twin TF33-P-103 power.
The Allison/Rolls commercial RB-211-535 has been considered,.
Others including the PW2040 (Which could be our F117-PW-200)
Read for the savings and thoughts on the topic;
http://www.acq.osd.mil/dsb/reports/ADA428790.pdf
Keep 'em flyin'
TEG
(Edit - added clarification of my F108 statement)
[Airplanes are] near perfect, all they lack is the ability to forgive.
— Richard Collins